scarc.library.oregonstate.edu/coll/pauling/blood/quotes/all.html
"Our postulate provides an obvious explanation of the action of oxygen in preventing the sickling of sickle-cell-anemia erythrocytes. We have visualized the sickling process as one in which complementary sites on adjacent hemoglobin molecules combine. It was suggested that erythrocytes containing oxyhemoglobin or carbonmonoxyhemoglobin do not sickle because of steric hindrance of the attached oxygen or carbon monoxide molecule. This steric hindrance effect might be the distortion of the complementary sites through forcing apart of layers of protein, as is suggested by the isocyanide experiments."
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